JumboBuc
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Not an ideal location for lab space unless it is hospital-associated lab space. You'd be surprised how oddly zip code specific biotechs can be when looking for space, even in a super tight market like Kendall. A local real estate guy I know told me how even though some of these guys could build / occupy on the Boston side of the pike, they all feel they need to be in Cambridge unless they have made the decision to be on 128 or 495.
This building's proximity to Longwood will be 100% of its marketing appeal. It shares a zip code with BIDMC and DFCI and is right down the street from BWH, BCH, and the whole HMS/HSPH complex (among others). Merck chose to put their research labs here, not in Cambridge. Also, the main tenants of the existing office complex it is being added to include BCH (257k sf!), HMS, Harvard Pilgrim Healthcare Institute, and HSPH. BI also has a research building three doors up Brookline Ave from here, and BCH has a whole 'nother building around the corner on Boylston.
Even putting aside the Longwood center-of-gravity, biotech lab developers and tenants have been showing a willingness to reach beyond Kendall in recent months. See the whole Foundation Medicine move to the Seaport (580k sf, the biggest lease of any type in the city since Vertex's move in 2011), plus Alexandria's GE purchase and Related Beal's Gillette purchase paving the way for a new multi-developer lab neighborhood along Fort Point Channel. Then there's the whole boom in "Cambridge Crossing," which is still mostly in Cambridge but outside of Kendall's traditional center.
Unless we hit a recession (in which location won't really matter) I suspect Samuels will have as much difficulty filling this as he had filling his commercial spaces in Landmark or above Target.