Other than keeping it in good repair, I don't see any reason to put more resources into our highway infrastructure.
I would add fixing standards-deficient stretches as a priority. A lot of that mid-1950's construction doesn't come close to meeting modern interstate standards. Stuff like regulation-sized shoulders, acceleration/deceleration lane lengthenings around ramps, and fixing overtight ramp curves are good investments purely on safety reasons. But also for congestion. I guess, though, you could lump that under the state-of-good-repair umbrella. MassHighway has done a pretty good job getting its roads up-to-standard outside of the city where it's easier.
I would have no problem with the following, since they fix highly substandard trouble spots:
-- Route 1/NE Expressway curve and weaving improvements.
-- 1A road geometry improvements north of Logan. High-speed tolls at the Sumner Tunnel would also open up the space to fix that curve in both directions and eliminate the side street intermixing.
-- A substantial Lowell (Deathtrap) Connector rebuild and exit ramp re-spacing.
-- The small-scale breakdown lane improvements where possible on the SE Expressway.
-- Finishing the last 2 miles of 146 in Millbury-Sutton (in design).
-- Braintree split, Canton split, 93/128 Peabody, 95/295 upgrades to those ridiculous turning radii and/or weaving zones on the incomplete interchanges, and drawing out over-dense ramp concentrations (e.g. Route 37 and Furnace Brook Pkwy. exits way too close to Braintree split) near those interchanges.
-- Route 2 Crosby's Corner (construction pending) and Concord Rotary (in design) grade separations. Alewife fix (NOW PLEASE!!!). 128 to Bedford Rd. grade separation (really easy, being studied). Go back and close out the last few Leominster grade separations they didn't take care of in the 90's when the rest of the road was rebuilt. Not sure how many curb cuts that leaves between Bedford Rd. and Crosby's Corner, but possible we could see contiguous expressways Acton-west and Concord-east with only minor closeouts after the big two elimination projects are done.
-- Picking off any remaining substandard exit ramps on 128, 495, 24, as those roads can reasonably achieve full standards compliance without a ton more money. Plus other awful bottlenecks and safety concerns of note like 91/5/57 Longmeadow rotaries and lane drop, 291/Pike intersection in Springfield, 140/24 in Taunton, 195/79 interchange Fall River (scheduled soon), 24/79/Highland Ave. merges in Fall River (left merges, blind curves, all-around deathtrap), 1A/16 rotary, 495/44/28/18 interchange + rotary.
-- Bourne flyover and rotary elimination (in design).
-- Ending once and for all Mass.'s insane rush hour breakdown lane travel. It's mercifully over on 128 in Dedham next year, and Needham in three years. If this means Route 3 has to go to six lanes from Duxbury and Weymouth, so be it. That is one of the worst practices ever, and I can't believe it's lasted this long.
-- *Judicious* add-a-lanes on small stretches: 24 Taunton from 495 to 140, 195 New Bedford/Fairhaven from 140 to 240, 495 Taunton/Middleboro from 24 to 79/105, 91 Chicopee from 202 to 5. And I guess they're gonna have to study a few biggies like 3 Duxbury-Weymouth to eliminate the breakdown lane travel, Pike from 84 to 291 for lack of other options (not a high induced demand risk because of extremely sparse exit spacing), and 91 to 5 in Northampton for exploding population and lack of better options. But that's it. I'd ban expanding anything to 8 lanes when 128 is done, outside of any needed acceleration/deceleration lanes at major interchanges. And would seriously resist any other 6-lane expansions except for the little ones and the really intractible or unsolveable-by-other-means ones like 3/breakdown lane or Pike through Central MA.
Beyond that there's not much other than studying new Pike exits in Boston; Super-2 grade separations and/or 4-lane upgrades on 6 from Dennis to Brewster, 44 expressway in Middleboro on the last unfinished stretch, and 88 in Westport from 195 to 177 (high crash rate, median barrier isn't working nearly as well as hoped); maybe some more easy Route 2 separation segments like the 111 concurrency in Acton to the (replaced) rotary; completing the last 1.5 mile leg of Route 57 to Southwick; and building the 1/2 mile Attleboro Connector off the 295 stub ramps to 152 as relief valve for downtown and the 95/123 exit. All pretty much little cleanups attached to other pending or recently (i.e. '95-05 decade) completed projects, and stuff with pretty broad community support like Attleboro Connector.
Really, compared to other New England states like CT that still have very choppy gaps and controversies (CT 11, I-384, US 7) that will never ever die, our highway system is as fully built as it can get. Inside 128 is off-limits (though I think they might want to look at full 1A grade separation from Eastie to 16), all the other in-state cities are built out, nearly all the major highway revolts were proven more or less correct by history, and most of what we do have is contiguous except for those little bits of low-hanging closeout pieces detailed above. Maybe the Bourne-Sagamore Southside Connector becomes reality (another low-hanging one on the build, albeit with induced demand anxiety), but that's the only substantial new-new one I could ever see moving forward. And in fact we may see just as much mileage in urban highway teardowns as we see with new builds and up-to-spec expressway upgrades with how things are shaping up on 79 in Fall River, Casey and Bowker overpasses on the parkways, the Rutherford Ave. downgrade studies, and the overwhelming support for blowing up McGrath Hwy. Maybe we even gain the courage in a few decades to pull the plug on Storrow.