DFCI proposes to construct a new building on three adjacent parcels presently occupied by 454 Brookline Avenue, the Redstone Building, and a 30-space surface parking lot. This building will have connections to the Smith Building, which is located on two lots situated immediately to the south of 454 Brookline Avenue and the Redstone parcels. DFCI is in the process of consolidating the above-referenced five lots into a single lot, which will be the site of the existing Smith Building and the Center for Cancer Care. The outdated one and two-story buildings on the 454 Brookline Avenue and Redstone lots represent an under-utilized resource in a prime location. The proposed 13-story Center for Cancer Care at 450 Brookline Avenue will present a significant, visible public presence and sense of entry to the Institute campus. The building will provide approximately 275,000 GSF of above-grade space that will accommodate clinical programs, patient and family services, clinical support space, new main lobby, retail space, and below-grade parking. The Center for Cancer Care will be the first new clinical building to be constructed on the DFCI campus in 30 years. It is designed to provide ample, state-of-the-art facilities for leading-edge treatment of cancer and related diseases for an expanded patient population. It will create an enhanced healing environment with a strong patient and family centered focus, improved patient safety, and support for safe staff practices. The project offers a critical opportunity to represent the Institute?s forward-looking vision and to reorient many campus functions, patterns of movement and interactions. It will serve as the new entrance not only to the DFCI campus but also to the Dana-Farber/Brigham and Women?s Cancer Center (DF/BWCC) and the DF/CHCC. The Center for Cancer Care will incorporate sustainable design features that underscore DFCI?s commitment to creating a healthy environment for patients, staff and the community. To enhance the collaboration between clinicians and researchers considered vital in the fight against cancer, the Center for Cancer Care will be connected on nine levels to the adjacent Smith Laboratories Building. The new entrance, accessible from both Brookline Avenue and Jimmy Fund Way, will feature a two-story lobby/atrium providing access to the third-level walkway system that links all of DFCI?s buildings and connects with Children?s and Brigham and Women?s hospitals. The new entrance and significant institutional presence will reorient the public face of Dana-Farber to Brookline Avenue, away from the existing ineffectual entrance on Binney Street. Construction of a tunnel under Jimmy Fund Way is proposed to connect the Center for Cancer Care with clinical support facilities in the Dana Building and to facilitate service access between the Dana Building, Center for Cancer Care, Smith Laboratories Building, and the upgraded Smith loading dock.